hsd11b2 proteintech Search Results


hsd11b2  (Proteintech)
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Proteintech hsd11b2
KEGG pathway analysis of DEGs related with CRA
Hsd11b2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hsd11b2 - by Bioz Stars, 2026-09
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KEGG pathway analysis of DEGs related with CRA

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: KEGG pathway analysis of DEGs related with CRA

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques:

Performance of PPI network and module analysis based on downregulated genes. A The whole PPI network of downregulated genes. B-D PPI networks of top three modules in downregulated DEGs through MCODE arithmetic. The top1 includes 6 nodes (GCG, CHGB/A, SST, INSM1, and NEUROD1) and 14 edges. The top2 contains 3 nodes (NR3C1, SGK1, and HSD11B2) and 3 edges. The top3 consists of 3 nodes (CA1/2/7) and 3 edges

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: Performance of PPI network and module analysis based on downregulated genes. A The whole PPI network of downregulated genes. B-D PPI networks of top three modules in downregulated DEGs through MCODE arithmetic. The top1 includes 6 nodes (GCG, CHGB/A, SST, INSM1, and NEUROD1) and 14 edges. The top2 contains 3 nodes (NR3C1, SGK1, and HSD11B2) and 3 edges. The top3 consists of 3 nodes (CA1/2/7) and 3 edges

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques:

Screening and verification of the hub genes by RT-qPCR. A-D The relative expression of REG1A, CA2 and HSD11B2 between colorectal mucosa and adenoma were measured by RT-qPCR ( p -value < 0.01). TIMP1 had no significant difference. E ROC curve with corresponding AUC value for hub genes when classifying CRA from mucosa. *** indicates p- value < 0.001, ** indicates p- value < 0.01, NS, none significance

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: Screening and verification of the hub genes by RT-qPCR. A-D The relative expression of REG1A, CA2 and HSD11B2 between colorectal mucosa and adenoma were measured by RT-qPCR ( p -value < 0.01). TIMP1 had no significant difference. E ROC curve with corresponding AUC value for hub genes when classifying CRA from mucosa. *** indicates p- value < 0.001, ** indicates p- value < 0.01, NS, none significance

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques: Quantitative RT-PCR, Expressing

Confirming the expression of CA2 and HSD11B2 by IHC. A IHC of CA2 and HSD11B2 between colorectal mucosa and adenoma. B IHC scores of CA2 and HSD11B2. C ROC curve with corresponding AUC were valued by MedCalc based on the IHC scores of hub genes. *** indicates p- value < 0.001, ** indicates p- value < 0.01, * indicate p- value < 0.05; Scale bar, 200 μm

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: Confirming the expression of CA2 and HSD11B2 by IHC. A IHC of CA2 and HSD11B2 between colorectal mucosa and adenoma. B IHC scores of CA2 and HSD11B2. C ROC curve with corresponding AUC were valued by MedCalc based on the IHC scores of hub genes. *** indicates p- value < 0.001, ** indicates p- value < 0.01, * indicate p- value < 0.05; Scale bar, 200 μm

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques: Expressing

Relationship between CA2 and HSD11B2 expression and immune cell infiltration in CRA. A The 22 immune cells infiltrated among different tissues in GSE8671 and GSE37364. B The comparisons of 22 infiltrated immune cells between colorectal mucosa and adenoma. C The relationship of core genes (CA2 and HSD11B2) and 22 immune cell types

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: Relationship between CA2 and HSD11B2 expression and immune cell infiltration in CRA. A The 22 immune cells infiltrated among different tissues in GSE8671 and GSE37364. B The comparisons of 22 infiltrated immune cells between colorectal mucosa and adenoma. C The relationship of core genes (CA2 and HSD11B2) and 22 immune cell types

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques: Expressing

Risk score analysis and Kaplan–Meier (KM) survival curves for COAD with high and low CA2 and HSD11B2 mRNA expression in GEPIA. A-B CA2 and HSD11B2 expression levols in COAD according to TCGA database. T, tumor; N, normal. The number of tumors was 275, and the number of normal tissues was 41. C Construction of the core genes risk score analysis in the TCGA dataset (clinical characteristics of 330 patients) including risk score, survival time and gene expression. D-E KM survival curves for overall survival ( p -value = 0.021) and disease free survival ( p -value = 0.16) in COAD according to CA2 expression. (F-G) KM survival curves for overall survival ( p -value = 0.69) and disease free survival ( p -value = 0.022) in COAD according to HSD11B2 expression. COAD, colon adenocarcinoma. * indicate p -value < 0.05. HR: hazard ratios. The dotted line as the 95% CI

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: Risk score analysis and Kaplan–Meier (KM) survival curves for COAD with high and low CA2 and HSD11B2 mRNA expression in GEPIA. A-B CA2 and HSD11B2 expression levols in COAD according to TCGA database. T, tumor; N, normal. The number of tumors was 275, and the number of normal tissues was 41. C Construction of the core genes risk score analysis in the TCGA dataset (clinical characteristics of 330 patients) including risk score, survival time and gene expression. D-E KM survival curves for overall survival ( p -value = 0.021) and disease free survival ( p -value = 0.16) in COAD according to CA2 expression. (F-G) KM survival curves for overall survival ( p -value = 0.69) and disease free survival ( p -value = 0.022) in COAD according to HSD11B2 expression. COAD, colon adenocarcinoma. * indicate p -value < 0.05. HR: hazard ratios. The dotted line as the 95% CI

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques: Expressing, Gene Expression

GO pathway analysis of downregulated DEGs related with CRA

Journal: BMC Cancer

Article Title: Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma

doi: 10.1186/s12885-022-10422-9

Figure Lengend Snippet: GO pathway analysis of downregulated DEGs related with CRA

Article Snippet: The CA2 (GeneTex, GTX105562) and HSD11B2 (Proteintech, 14,192–1-AP) antibodies were utilized for IHC according to their protocols.

Techniques: Migration, Activity Assay